Erstwhile triple threat

The triple threat of aspiration pneumonia.

A spiration pneumonia is a disease recognized since antiquity, yet there are few conditions in pulmonary medicine as frequent in occurrence but as lacking in consensus regarding classification and treatment. The priority for clinical description belongs to Hippocrates,’ the first scientific investigalion is ascribed to John Hunters in 1781, and the “classic study” is credited to Mendelson in 19...

Triple threat: adiposity, aging, atrial fibrillation

FMRP: a triple threat to PSD-95

Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al., 2008). There is a strong genetic basis for autism, which is highly comorbid with singlegene disorders including fragile X syndrome (FXS) (Wang et al., 2010). The main challenges that have plagued the field incl...

Reminiscences of an Erstwhile Student

In 1933 the Dean interviewed applicants for the Yale Medical School from the depths of a big chair at an enormous shiny table. I can't remember any thing about the room-probably because I never took my eyes off the man in the chair. Rumor had painted this interview as a shattering affair. Although I had been I.Q.ed, testimonialed, and bolstered with academic records, I was nervous and numb. I k...

Heme oxygenase-1: a multifaceted triple-threat molecule.

Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the antioxidant, anti...